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In turn, phosphorylation of the adaptor proteins insulin receptor substrate 14 (IRS-14) and Shc leads to activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways (Baserga, 2000)

Low NAD levels are linked to oxidative stress, free radical damage, and age-related diseases 8 such as: Diabetes Neurodegenerative disorders Vascular damage Accelerated aging By restoring NAD, 5-Amino-1MQ helps reduce oxidative stress, protecting cells, DNA, and proteins from damage

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